How To Reverse Aging: David Sinclair and The Disease of Aging

Sep 28, 2023 28 Min Video
Reversed Aging
Understanding How You Can Grow Younger With Simple Interventions

In this episode, I share the science behind aging and the possibilities of reversing the process of aging. I dive into the work of David Sinclair, professor of genetics at Harvard Medical School, whose recent breakthrough saw him and his team reset aging cells in mice to earlier versions of themselves. Join us for this edition of Wellness Wednesday as we dive into how we may possibly live longer!

David Sinclair is pushing the boundaries of what we understand about aging. He’s a professor of genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging. This guy isn’t just working to slow down aging; he's aiming to reverse it! Quite ambitious, if you ask me, but isn't that what pioneers are made of?  In this video, you will hear some of Sinclair's work on aging. Sinclair focuses on cellular pathways that influence aging, including sirtuins. Ever heard of them? Sirtuins are a family of proteins that play a role in aging by controlling cellular health. Sinclair and his team have explored the role of sirtuins in DNA repair and gene regulation, and they found out that these proteins can, in fact, be activated.

One of the buzzwords you'll find in Sinclair’s work is "NAD+," a molecule that’s essential for cellular energy and declines as we age. By increasing levels of NAD+, one could theoretically enhance sirtuin activity. Sinclair's studies on mice showed that supplementing with NAD+ precursors could actually reverse aspects of aging. Just imagine what that could mean for us humans! Sinclair’s work also delves into something called epigenetic reprogramming. You see, as cells age, they gain epigenetic marks, sort of like wrinkles on your skin but at the cellular level. Epigenetic reprogramming is like giving these cells a spa day, making them act young again. Now, how many of you would give an arm and a leg for that? No need! Sinclair suggests we could simply modify our lifestyles or take specific compounds that act as activators of these age-defying pathways.

So, how can we apply this to our lives? Well, some common takeaways relate to calorie restriction, exercise, and intermittent fasting, which have been shown to boost sirtuin activity. If fasting isn’t your cup of tea, there are also supplements like resveratrol, found in red wine, and NMN, a NAD+ precursor, available in the market. But hold your horses! Always consult your doctor before jumping onto any supplement bandwagon, especially if you're not aging like George Clooney. Now, do you remember Popeye? The guy had it figured out when it came to spinach. Eating leafy greens, nuts, and berries can also be a great addition to boosting your sirtuin activity, given their rich polyphenol content. While Sinclair's work is revolutionary, it’s crucial to note that his research is still in its infancy when it comes to human applications. So, don’t chuck your wrinkle cream just yet. However, the future looks promising. Imagine a world where getting older doesn’t mean giving up the activities you love or losing your independence. It's a world I’d definitely want to grow old in, or should I say, “grow young”?


Remember folks, aging might be inevitable, but how you age is definitely negotiable. So, watch this video and keep young forever

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Roshan is the Founder and “Kuli” of the Leaderonomics Group of companies. He believes that everyone can be a leader and "make a dent in the universe," in their own special ways. He is featured on TV, radio and numerous publications sharing the Science of Building Leaders and on leadership development. Follow him at


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